From HollywoodInsider.com:
Look who’s hot for…Two and A Half Men! Eddie Van Halen will play himself in an episode when the CBS comedy returns Sept. 21, executive producer Chuck Lorre confirmed to EW exclusively. Lorre approached the guitar god – while on his recent honeymoon, no less! – after learning he was a big fan of the sitcom. “He was gracious enough to do a cameo, which is really cool,” Lorre said.
Van Halen’s scene is expected to tape this week in Burbank, CA. And yes, promises Lorre, Van Halen will play the guitar.